Signalling and sex in the social amoebozoans
Identifieur interne : 001339 ( Main/Exploration ); précédent : 001338; suivant : 001340Signalling and sex in the social amoebozoans
Auteurs : Danton H. O'Day [Canada] ; Alex Keszei [Canada]Source :
- Biological Reviews [ 1464-7931 ] ; 2012-05.
Abstract
The social amoebozoans have a life tricycle consisting of asexual multicellular development leading to fruiting bodies, sexual multicellular development resulting in macrocysts, and unicellular development generating microcysts. This review covers the events of sexual development in the best‐studied heterothallic (Dictyostelium discoideum) and homothallic (D. mucoroides) mating systems. Sexual development begins with pheromonal interactions that produce fusion‐competent cells (gametes) which undergo cell and pronuclear fusion. Calcium‐ and calmodulin‐mediated signalling mediates these early events. As they initiate chemotactic signalling, each zygote increases in size becoming a zygote giant cell. Using cyclic AMP (cAMP), the zygote chemotactically lures in amoebae and engulfs them in an act of cannibalistic phagocytosis. Chemotaxis proceeds more quickly than endocytosis because the breakdown products of cAMP (5‐AMP, adenosine) bind to a presumptive adenosine receptor to inhibit sexual phagocytosis. This slowing of phagocytosis allows amoebae to accumulate around the zygote to form a precyst aggregate. Zygote giant cells also produce several other signalling molecules that feed back to regulate early events. The amoebae surrounding the zygote seal their fate as zygotic foodstuff by secreting a primary cellulose wall, the extracellular sheath, around the zygote and aggregated amoebae, which prevents their escape. Phagocytosis within this precyst continues until all peripheral amoebae are internalized as endocytes and the final macrocyst wall is formed. Endocyte digestion results in a mature macrocyst with a uniform cytoplasm containing a diploid nucleus. After detailing the morphological events of heterothallic and homothallic mating, we review the various intercellular signalling events and other mechanisms involved in each stage. This complete and comprehensive review sets the stage for future research on the unique events that characterize sex in the social amoebozoans.
Url:
DOI: 10.1111/j.1469-185X.2011.00200.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002453
- to stream Istex, to step Curation: 002453
- to stream Istex, to step Checkpoint: 000348
- to stream Main, to step Merge: 001340
- to stream Main, to step Curation: 001339
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Signalling and sex in the social amoebozoans</title><author><name sortKey="O Day, Danton H" sort="O Day, Danton H" uniqKey="O Day D" first="Danton H." last="O'Day">Danton H. O'Day</name></author><author><name sortKey="Keszei, Alex" sort="Keszei, Alex" uniqKey="Keszei A" first="Alex" last="Keszei">Alex Keszei</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6076635633E7BB7D1BD44423D1387E0C889F08D7</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1111/j.1469-185X.2011.00200.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-7FGKM92S-4/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002453</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002453</idno><idno type="wicri:Area/Istex/Curation">002453</idno><idno type="wicri:Area/Istex/Checkpoint">000348</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000348</idno><idno type="wicri:doubleKey">1464-7931:2012:O Day D:signalling:and:sex</idno><idno type="wicri:Area/Main/Merge">001340</idno><idno type="wicri:Area/Main/Curation">001339</idno><idno type="wicri:Area/Main/Exploration">001339</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Signalling and sex in the social amoebozoans</title><author><name sortKey="O Day, Danton H" sort="O Day, Danton H" uniqKey="O Day D" first="Danton H." last="O'Day">Danton H. O'Day</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biology, University of Toronto at Mississauga, Mississauga, Ontario L5L 1C6</wicri:regionArea><wicri:noRegion>Ontario L5L 1C6</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation></author><author><name sortKey="Keszei, Alex" sort="Keszei, Alex" uniqKey="Keszei A" first="Alex" last="Keszei">Alex Keszei</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3G5</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Biological Reviews</title><title level="j" type="alt">BIOLOGICAL REVIEWS</title><idno type="ISSN">1464-7931</idno><idno type="eISSN">1469-185X</idno><imprint><biblScope unit="vol">87</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="313">313</biblScope><biblScope unit="page" to="329">329</biblScope><biblScope unit="page-count">17</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-05">2012-05</date></imprint><idno type="ISSN">1464-7931</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1464-7931</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The social amoebozoans have a life tricycle consisting of asexual multicellular development leading to fruiting bodies, sexual multicellular development resulting in macrocysts, and unicellular development generating microcysts. This review covers the events of sexual development in the best‐studied heterothallic (Dictyostelium discoideum) and homothallic (D. mucoroides) mating systems. Sexual development begins with pheromonal interactions that produce fusion‐competent cells (gametes) which undergo cell and pronuclear fusion. Calcium‐ and calmodulin‐mediated signalling mediates these early events. As they initiate chemotactic signalling, each zygote increases in size becoming a zygote giant cell. Using cyclic AMP (cAMP), the zygote chemotactically lures in amoebae and engulfs them in an act of cannibalistic phagocytosis. Chemotaxis proceeds more quickly than endocytosis because the breakdown products of cAMP (5‐AMP, adenosine) bind to a presumptive adenosine receptor to inhibit sexual phagocytosis. This slowing of phagocytosis allows amoebae to accumulate around the zygote to form a precyst aggregate. Zygote giant cells also produce several other signalling molecules that feed back to regulate early events. The amoebae surrounding the zygote seal their fate as zygotic foodstuff by secreting a primary cellulose wall, the extracellular sheath, around the zygote and aggregated amoebae, which prevents their escape. Phagocytosis within this precyst continues until all peripheral amoebae are internalized as endocytes and the final macrocyst wall is formed. Endocyte digestion results in a mature macrocyst with a uniform cytoplasm containing a diploid nucleus. After detailing the morphological events of heterothallic and homothallic mating, we review the various intercellular signalling events and other mechanisms involved in each stage. This complete and comprehensive review sets the stage for future research on the unique events that characterize sex in the social amoebozoans.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="O Day, Danton H" sort="O Day, Danton H" uniqKey="O Day D" first="Danton H." last="O'Day">Danton H. O'Day</name></noRegion><name sortKey="Keszei, Alex" sort="Keszei, Alex" uniqKey="Keszei A" first="Alex" last="Keszei">Alex Keszei</name><name sortKey="O Day, Danton H" sort="O Day, Danton H" uniqKey="O Day D" first="Danton H." last="O'Day">Danton H. O'Day</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001339 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001339 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:6076635633E7BB7D1BD44423D1387E0C889F08D7
|texte= Signalling and sex in the social amoebozoans
}}
| This area was generated with Dilib version V0.6.33. |  |